E-mail: jiangxiue ciac. Cancer has become one of the primary threats to human beings, and traditional therapies including surgery, chemotherapy and radiotherapy show limited therapeutic efficacy due to the complexity of tumor biology. Furthermore, determining how to utilize the differences between the tumor microenvironment TME and healthy tissues and exploring new nanoplatforms that can realize early diagnosis and effective and non-toxic therapy are challenges in cancer theranostics.
Numerous researchers have designed multifunctional nanomaterials and investigated their personalized therapy and regulation abilities toward TME, including oxygen generation, glutathione consumption and the production of reactive oxygen species and multi-model imaging effects. This review will introduce the latest progress in the design of multi-functional nanomedicines for the regulation of TME and their theranostics, and it will provide a critical angle for the future development of nanomedicine.
Wenyao Zhen is now pursing her doctoral degree under the supervision of Prof. Currently, her research is focused on the design and synthesis of multifunctional nanomaterials with TME-sensitive properties for effective diagnosis and therapeutic systems.
Wenxue Hu is currently pursuing a Master's Degree instructed by Prof. She joined Prof. Jiang's group as a joint graduate student in Her research interests are the fabrication and applications of functional nanomaterials. Liang Dong is currently pursuing his Master's Degree under the supervision of Prof. Zhiai Xu and Prof. He joined Prof. His research interests include the fabrication of functional nanomaterials to load dihydroartemisinin and their applications in cancer diagnosis and treatment.
Shangjie An is currently pursuing her doctoral degree instructed by Prof. Her research interests include the development of functional nanomaterials and their applications in tumor therapy and diagnosis. Xiue Jiang received her Ph. Her current research interests include revealing the cellular response mechanisms at the nanoscale by various spectroscopy methods, especially surface-enhanced infrared spectroscopy, for biomedical applications.
